Hello, I have a small yeast infection on my Penis. I had it once and I took a Fluconazole pill and Nysatin cream and it went away. Like 3 months later I had intercourse with my wife and she gave it to me again. Some treatments start to work with just one dose, while others need to be taken over several days to cure a yeast infection. If you're not sure which treatment is right for you, speak with your doctor or pharmacist. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Cordero on how long to cure a yeast infection with fluconazole: It usually helps if you confirm that what you have is actually a yeast infection and then take an appropriate medication for it while you eat the yogurt. User Reviews for Fluconazole to treat Vaginal Yeast Infection. Also known as: Diflucan. The following information is NOT intended to endorse drugs or recommend therapy. DIFLUCAN ONE works by stopping the growth of the fungi that caused the yeast infection in the first place. Although you only need to take one pill, the medication in DIFLUCAN ONE, fluconazole 150 mg, continues working in your body for several days until your yeast infection is cured. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Livingston on how long does diflucan take to cure a yeast infection: Reported to assist in preventing development of yeast infections and to help decrease symtoms but is not considered a 'cure' for yeast infections. Fluconazole is a very effective treatment for yeast infection and it’s supported by numerous studies. It’s a mess-free option, as very often one pill is enough to cure your infection for good without the need of using suppositories. How long does it take for fluconazole to cure a vaginal yeast infection? Asked 5 Mar 2018 by jslibert123 Updated 6 March 2018 Topics infections, vaginal yeast infection, fluconazole, yeast infection, vagina What does Fluconazole do? Fluconazole is an anti fungal drug that is used to treat yeast infections. What it does exactly is, it kills fungus. It is the anti fungal ingredient that is used in the oral drug, Diflucan, and this is probably what you would get prescribed by your doctor if the Miconazole cream ( usually Monistat ) you have used hasn.